Hypoxia regulates FGFR3 expression via HIF-1α and miR-100 and contributes to cell survival in non-muscle invasive bladder cancer

BACKGROUND: Non-muscle invasive (NMI) bladder cancer is characterised by increased expression and activating mutations of FGFR3. We have previously investigated the role of microRNAs in bladder cancer and have shown that FGFR3 is a target of miR-100. In this study, we investigated the effects of hyp...

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Bibliografske podrobnosti
Main Authors: Blick, C, Ramachandran, A, Wigfield, S, McCormick, R, Jubb, A, Buffa, F M, Turley, H, Knowles, M A, Cranston, D, Catto, J, Harris, A L
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2013
Teme:
Clinical Study
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3708569/
https://ncbi.nlm.nih.gov/pubmed/23778527
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2013.240
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