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Tamoxifen induces rapid, reversible atrophy and metaplasia in mouse stomach

Tamoxifen, a selective estrogen receptor modulator, is widely used in research and clinically in patients. We find that treatment of normal mice with a single ≥ 3mg/20g body weight dose of tamoxifen leads to apoptosis of > 90% of all gastric parietal cells and metaplasia of zymogenic chief cells...

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Detalhes bibliográficos
Main Authors: Huh, Won Jae, Khurana, Shradha S., Geahlen, Jessica H., Kohli, Kavita, Waller, Rachel A., Mills, Jason C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3708546/
https://ncbi.nlm.nih.gov/pubmed/22001866
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2011.09.050
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