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Tamoxifen induces rapid, reversible atrophy and metaplasia in mouse stomach
Tamoxifen, a selective estrogen receptor modulator, is widely used in research and clinically in patients. We find that treatment of normal mice with a single ≥ 3mg/20g body weight dose of tamoxifen leads to apoptosis of > 90% of all gastric parietal cells and metaplasia of zymogenic chief cells...
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| Autors principals: | , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2011
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3708546/ https://ncbi.nlm.nih.gov/pubmed/22001866 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2011.09.050 |
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