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Down-regulation of integrins by von Hippel-Lindau (VHL) tumor suppressor protein is independent of VHL directed hypoxia-inducible factor alpha degradation
Inactivation of the von Hippel-Lindau (VHL) tumor suppressor gene occurs in the majority of clear-cell renal cell carcinomas (RCC). It was previously shown that VHL decreased the abundance of integrin α2, α5 and β1 – consistent with VHL-associated changes in cell-cell and cell-extracellular matrix a...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3708035/ https://ncbi.nlm.nih.gov/pubmed/18523483 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1139/o08-035 |
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