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Overlapping functions of ABC transporters in topotecan disposition as determined in gene knockout mouse models
It is established that efflux transporters of the ABC superfamily can affect the pharmacokinetics (PKs) of drugs through mechanisms pertaining to drug absorption, elimination and distribution. To characterize the role of multiple transporters in topotecan's PKs, total (lactone+carboxylate) and...
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| Autori principali: | , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2013
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3707957/ https://ncbi.nlm.nih.gov/pubmed/23635651 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-13-0100 |
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