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Phosphatidylinositol 4,5-Bisphosphate Decreases the Concentration of Ca(2+), Phosphatidylserine and Diacylglycerol Required for Protein Kinase C α to Reach Maximum Activity
The C2 domain of PKCα possesses two different binding sites, one for Ca(2+) and phosphatidylserine and a second one that binds PIP(2) with very high affinity. The enzymatic activity of PKCα was studied by activating it with large unilamellar lipid vesicles, varying the concentration of Ca(2+) and th...
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| Autors principals: | , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Public Library of Science
2013
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3707892/ https://ncbi.nlm.nih.gov/pubmed/23874859 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0069041 |
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