Binding of the CYK-4 Subunit of the Centralspindlin Complex Induces a Large Scale Conformational Change in the Kinesin Subunit

Centralspindlin is a critical regulator of cytokinesis in animal cells. It is a tetramer consisting of ZEN-4/MKLP1, a kinesin-6 motor, and CYK-4/MgcRacGAP, a Rho GTPase-activating protein. At anaphase, centralspindlin localizes to a narrow region of antiparallel microtubule overlap and initiates cen...

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Detaylı Bibliyografya
Asıl Yazarlar: White, Erin A., Raghuraman, Hariharasundaram, Perozo, Eduardo, Glotzer, Michael
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Biochemistry and Molecular Biology 2013
Konular:
Cell Biology
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3707682/
https://ncbi.nlm.nih.gov/pubmed/23720745
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.463695
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