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Differential Regulation of c-Jun Protein Plays an Instrumental Role in Chemoresistance of Cancer Cells

The chemotherapeutic drug cisplatin (cis-diamminedichloroplatinum(II) (CDDP)) is widely used in the treatment of human cancers. However, the mechanism underlying intrinsic tumor resistance to CDDP remains elusive. Here, we demonstrate that treatment with CDDP resulted in down-regulation of c-Jun exp...

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Detalhes bibliográficos
Main Authors: Xia, Yan, Yang, Weiwei, Bu, Wen, Ji, Haitao, Zhao, Xueqiang, Zheng, Yanhua, Lin, Xin, Li, Yi, Lu, Zhimin
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3707636/
https://ncbi.nlm.nih.gov/pubmed/23678002
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.475442
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