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Hybrid error correction and de novo assembly of single-molecule sequencing reads
Emerging single-molecule sequencing instruments can generate multi-kilobase sequences with the potential to dramatically improve genome and transcriptome assembly. However, the high error rate of single-molecule reads is challenging, and has limited their use to resequencing bacteria. To address thi...
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| Hauptverfasser: | , , , , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2012
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3707490/ https://ncbi.nlm.nih.gov/pubmed/22750884 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt.2280 |
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