Association between adrenergic receptor genotypes and beta-blocker dose in heart failure patients: analysis from the HF-ACTION DNA substudy

AIMS: Beta-blockers reduce morbidity and mortality in chronic heart failure (HF) patients with reduced ejection fraction. However, there is heterogeneity in the response to these drugs, perhaps due to genetic variations in the β1-adrenergic receptor (ADRβ1). We examined whether the Arg389Gly polymor...

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Détails bibliographiques
Auteurs principaux: Fiuzat, Mona, Neely, Megan L., Starr, Aijing Z., Kraus, William E., Felker, G. Michael, Donahue, Mark, Adams, Kirkwood, Piña, Ileana L., Whellan, David, O'Connor, Christopher M.
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2013
Sujets:
Genetics
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3707429/
https://ncbi.nlm.nih.gov/pubmed/23115322
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/eurjhf/hfs175
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