Association between adrenergic receptor genotypes and beta-blocker dose in heart failure patients: analysis from the HF-ACTION DNA substudy

AIMS: Beta-blockers reduce morbidity and mortality in chronic heart failure (HF) patients with reduced ejection fraction. However, there is heterogeneity in the response to these drugs, perhaps due to genetic variations in the β1-adrenergic receptor (ADRβ1). We examined whether the Arg389Gly polymor...

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Main Authors: Fiuzat, Mona, Neely, Megan L., Starr, Aijing Z., Kraus, William E., Felker, G. Michael, Donahue, Mark, Adams, Kirkwood, Piña, Ileana L., Whellan, David, O'Connor, Christopher M.
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2013
Fag:
Genetics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3707429/
https://ncbi.nlm.nih.gov/pubmed/23115322
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/eurjhf/hfs175
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