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Polymorphism at the C-reactive protein locus influences gene expression and predisposes to systemic lupus erythematosus

Relative deficiency of pentraxin proteins is implicated in the pathogenesis of systemic lupus erythematosus. The C-reactive protein (CRP) response is defective in patients with acute flares of disease, and mice with targeted deletions of the serum amyloid P component gene (Sap) develop a lupus-like...

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Detalhes bibliográficos
Main Authors: Russell, Andrew I., Graham, Deborah S. Cunninghame, Shepherd, Christopher, Roberton, Cheri A., Whittaker, John, Meeks, John, Powell, Richard J., Isenberg, David A., Walport, Mark J., Vyse, Timothy J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2003
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3707088/
https://ncbi.nlm.nih.gov/pubmed/14645206
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddh021
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