Identification and functional validation of HPV-mediated hypermethylation in head and neck squamous cell carcinoma

BACKGROUND: Human papillomavirus-positive (HPV+) head and neck squamous cell carcinoma (HNSCC) represents a distinct clinical and epidemiological condition compared with HPV-negative (HPV-) HNSCC. To test the possible involvement of epigenetic modulation by HPV in HNSCC, we conducted a genome-wide D...

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Main Authors: Lechner, Matthias, Fenton, Tim, West, James, Wilson, Gareth, Feber, Andrew, Henderson, Stephen, Thirlwell, Christina, Dibra, Harpreet K, Jay, Amrita, Butcher, Lee, Chakravarthy, Ankur R, Gratrix, Fiona, Patel, Nirali, Vaz, Francis, O'Flynn, Paul, Kalavrezos, Nicholas, Teschendorff, Andrew E, Boshoff, Chris, Beck, Stephan
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2013
Teme:
Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3706778/
https://ncbi.nlm.nih.gov/pubmed/23419152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/gm419
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