New Aspects of an Old Drug – Diclofenac Targets MYC and Glucose Metabolism in Tumor Cells

Non-steroidal anti-inflammatory drugs such as diclofenac exhibit potent anticancer effects. Up to now these effects were mainly attributed to its classical role as COX-inhibitor. Here we show novel COX-independent effects of diclofenac. Diclofenac significantly diminished MYC expression and modulate...

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Main Authors: Gottfried, Eva, Lang, Sven A., Renner, Kathrin, Bosserhoff, Anja, Gronwald, Wolfram, Rehli, Michael, Einhell, Sabine, Gedig, Isabel, Singer, Katrin, Seilbeck, Anton, Mackensen, Andreas, Grauer, Oliver, Hau, Peter, Dettmer, Katja, Andreesen, Reinhard, Oefner, Peter J., Kreutz, Marina
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2013
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3706586/
https://ncbi.nlm.nih.gov/pubmed/23874405
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0066987
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