Imaging dopamine transmission in the frontal cortex: a simultaneous microdiaysis and [(11)C]FLB 457 PET study

In a recent human PET study we demonstrated the ability to detect amphetamine-induced dopamine release in the prefrontal cortex as a reduction in the binding of the dopamine D(2/3) radioligand [(11)C]FLB 457. A key requirement for validating this paradigm for use in clinical studies is demonstrating...

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Autors principals: Narendran, Rajesh, Jedema, Hank P., Lopresti, Brian J., Mason, Neale Scott, Gurnsey, Kate, Ruszkiewicz, James, Chen, Chi-Min, Deuitch, Lora, Frankle, W. Gordon, Bradberry, Charles W.
Format: Artigo
Idioma:Inglês
Publicat: 2013
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3706503/
https://ncbi.nlm.nih.gov/pubmed/23439486
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mp.2013.9
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