Drug-Associated Changes in Amino Acid Residues in Gag p2, p7(NC), and p6(Gag)/p6(Pol) in Human Immunodeficiency Virus Type 1 (HIV-1) Display a Dominant Effect on Replicative Fitness and Drug Response

Regions of HIV-1 gag between p2 and p6(Gag)/p6(Pol), in addition to protease (PR), develop genetic diversity in HIV-1 infected individuals who fail to suppress virus replication by combination protease inhibitor (PI) therapy. To elucidate functional consequences for viral replication and PI suscepti...

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Autori principali: Ho, Sarah K., Coman, Roxana M., Bunger, Joshua, Rose, Stephanie L., O’Brien, Patricia, Munoz, Isabel, Dunn, Ben M., Sleasman, John W., Goodenow, Maureen M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2008
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3706456/
https://ncbi.nlm.nih.gov/pubmed/18599104
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2008.05.029
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