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Optimal assembly for high throughput shotgun sequencing

We present a framework for the design of optimal assembly algorithms for shotgun sequencing under the criterion of complete reconstruction. We derive a lower bound on the read length and the coverage depth required for reconstruction in terms of the repeat statistics of the genome. Building on earli...

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Hlavní autoři: Bresler, Guy, Bresler, Ma'ayan, Tse, David
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2013
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3706340/
https://ncbi.nlm.nih.gov/pubmed/23902516
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2105-14-S5-S18
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