The metabolic bioactivation of caffeic acid phenethyl ester (CAPE) mediated by tyrosinase selectively inhibits glutathione S-transferase

Glutathione S-transferase (GST) and multidrug resistance-associated proteins (MRPs) play major roles in drug resistance in melanoma. In this study, we investigated caffeic acid phenethyl ester (CAPE) as a selective GST inhibitor in the presence of tyrosinase, which is abundant in melanoma cells. Tyr...

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Main Authors: Kudugunti, Shashi K., Thorsheim, Helen, Yousef, Mohammad S., Guan, Lan, Moridani, Majid Y.
格式: Artigo
語言:Inglês
出版: 2011
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3706206/
https://ncbi.nlm.nih.gov/pubmed/21458432
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cbi.2011.03.015
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