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BRCA1-Dependent Chk1 Phosphorylation Triggers Partial Chromatin Disassociation of Phosphorylated Chk1 and Facilitates S-Phase Cell Cycle Arrest
[Image: see text] Chk1 phosphorylation by the PI3-like kinases ATR and ATM is critical for its activation and its role in prevention of premature mitotic entry in response to DNA damage or stalled replication. The breast and ovarian tumor suppressor, BRCA1, is among several checkpoint mediators that...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3706104/ https://ncbi.nlm.nih.gov/pubmed/22743332 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biocel.2012.06.026 |
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