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The myosin-binding UCS domain but not the Hsp90-binding TPR domain of the UNC-45 chaperone is essential for function in Caenorhabditis elegans

The UNC-45 family of molecular chaperones is expressed in metazoan organisms from Caenorhabditis elegans to humans. The UNC-45 protein is essential in C. elegans for early body-wall muscle cell development and A-band assembly. We show that the myosin-binding UCS domain of UNC-45 alone is sufficient...

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Detalhes bibliográficos
Main Authors: Ni, Weiming, Hutagalung, Alex H., Li, Shumin, Epstein, Henry F.
Formato: Artigo
Idioma:Inglês
Publicado em: Company of Biologists 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3706032/
https://ncbi.nlm.nih.gov/pubmed/21914819
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.087320
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