Posttranslational Nitration of Tyrosine Residues Modulates Glutamate Transmission and Contributes to N-Methyl-D-aspartate-Mediated Thermal Hyperalgesia

Activation of the N-methyl-D-aspartate receptor (NMDAR) is fundamental in the development of hyperalgesia. Overactivation of this receptor releases superoxide and nitric oxide that, in turn, forms peroxynitrite (PN). All of these events have been linked to neurotoxicity. The receptors and enzymes in...

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Autori principali: Muscoli, Carolina, Dagostino, Concetta, Ilari, Sara, Lauro, Filomena, Gliozzi, Micaela, Bardhi, Erlisa, Palma, Ernesto, Mollace, Vincenzo, Salvemini, Daniela
Natura: Artigo
Lingua:Inglês
Pubblicazione: Hindawi Publishing Corporation 2013
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3705874/
https://ncbi.nlm.nih.gov/pubmed/23864769
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2013/950947
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