In vivo NADH fluorescence imaging indicates effect of aquaporin-4 deletion on oxygen microdistribution in cortical spreading depression

Using in vivo two-photon imaging, we show that mice deficient in aquaporin-4 (AQP4) display increased fluorescence of nicotinamide adenine dinucleotide (NADH) when subjected to cortical spreading depression. The increased NADH signal, a proxy of tissue hypoxia, was restricted to microwatershed areas...

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Detalhes bibliográficos
Main Authors: Thrane, Alexander S, Takano, Takahiro, Thrane, Vinita Rangroo, Wang, Fushun, Peng, Weiguo, Ottersen, Ole Petter, Nedergaard, Maiken, Nagelhus, Erlend A
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2013
Assuntos:
Brief Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3705443/
https://ncbi.nlm.nih.gov/pubmed/23611872
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jcbfm.2013.63
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