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A Conus regularis Conotoxin with a Novel Eight-Cysteine Framework Inhibits Ca(V)2.2 Channels and Displays an Anti-Nociceptive Activity

A novel peptide, RsXXIVA, was isolated from the venom duct of Conus regularis, a worm-hunting species collected in the Sea of Cortez, México. Its primary structure was determined by mass spectrometry and confirmed by automated Edman degradation. This conotoxin contains 40 amino acids and exhibits a...

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Detalhes bibliográficos
Main Authors: Bernáldez, Johanna, Román-González, Sergio A., Martínez, Oscar, Jiménez, Samanta, Vivas, Oscar, Arenas, Isabel, Corzo, Gerardo, Arreguín, Roberto, García, David E., Possani, Lourival D., Licea, Alexei
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2013
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3705398/
https://ncbi.nlm.nih.gov/pubmed/23567319
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/md11041188
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