Chronic glucolipotoxic conditions in pancreatic islets impair insulin secretion due to dysregulated calcium dynamics, glucose responsiveness and mitochondrial activity

BACKGROUND: In the progression towards diabetes, glucolipotoxicity is one of the main causes of pancreatic beta cell pathology. The aim of this study was to examine the in vitro effects of chronic glucolipotoxic conditions on cellular responses in pancreatic islets, including glucose and fat metabol...

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Main Authors: Somesh, Baggavalli P, Verma, Mahesh Kumar, Sadasivuni, Manoj Kumar, Mammen-Oommen, Anup, Biswas, Sanghamitra, Shilpa, Pavagada C, Reddy, Ashok Kumar, Yateesh, Aggunda N, Pallavi, Puttrevana M, Nethra, Siddaraju, Smitha, Rachapalli, Neelima, Korrapati, Narayanan, Usha, Jagannath, Madanahalli R
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3704974/
https://ncbi.nlm.nih.gov/pubmed/23815372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2121-14-31
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