IGFBP5 Domains Exert Distinct Inhibitory Effects on the Tumorigenicity and Metastasis of Human Osteosarcoma

Osteosarcoma (OS) is the most common primary malignancy of bone. We investigated the roles of insulin-like growth factor binding protein 5 (IGFBP5) domains in modulating OS tumorigenicity and metastasis. The N-terminal (to a lesser extent the C-terminal) domain inhibited cell proliferation and induc...

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Detalhes bibliográficos
Main Authors: Luther, Gaurav A., Lamplot, Joseph, Chen, Xiang, Rames, Richard, Wagner, Eric R., Liu, Xing, Parekh, Akash, Huang, Enyi, Kim, Stephanie H., Shen, Jikun, Haydon, Rex C., He, Tong-Chuan, Luu, Hue H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3704951/
https://ncbi.nlm.nih.gov/pubmed/23665505
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.canlet.2013.05.002
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