Identification of Novel Variants in Colorectal Cancer Families by High-Throughput Exome Sequencing

BACKGROUND: Colorectal cancer (CRC) in densely affected families without Lynch Syndrome may be due to mutations in undiscovered genetic loci. Familial linkage analyses have yielded disparate results; the use of exome sequencing in coding regions may identify novel segregating variants. METHODS: We c...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: DeRycke, Melissa S., Gunawardena, Shanaka R., Middha, Sumit, Asmann, Yan W, Schaid, Daniel J., McDonnell, Shannon K., Riska, Shaun M., Eckloff, Bruce W, Cunningham, Julie M., Fridley, Brooke L., Serie, Daniel J., Bamlet, William R., Cicek, Mine S., Jenkins, Mark A., Duggan, David J., Buchanan, Daniel, Clendenning, Mark, Haile, Robert W., Woods, Michael O., Gallinger, Steven N., Casey, Graham, Potter, John D., Newcomb, Polly A., Le Marchand, Loic, Lindor, Noralane M., Thibodeau, Stephen N., Goode, Ellen L.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3704223/
https://ncbi.nlm.nih.gov/pubmed/23637064
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1055-9965.EPI-12-1226
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky