Identification of Novel Variants in Colorectal Cancer Families by High-Throughput Exome Sequencing

BACKGROUND: Colorectal cancer (CRC) in densely affected families without Lynch Syndrome may be due to mutations in undiscovered genetic loci. Familial linkage analyses have yielded disparate results; the use of exome sequencing in coding regions may identify novel segregating variants. METHODS: We c...

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Autori principali: DeRycke, Melissa S., Gunawardena, Shanaka R., Middha, Sumit, Asmann, Yan W, Schaid, Daniel J., McDonnell, Shannon K., Riska, Shaun M., Eckloff, Bruce W, Cunningham, Julie M., Fridley, Brooke L., Serie, Daniel J., Bamlet, William R., Cicek, Mine S., Jenkins, Mark A., Duggan, David J., Buchanan, Daniel, Clendenning, Mark, Haile, Robert W., Woods, Michael O., Gallinger, Steven N., Casey, Graham, Potter, John D., Newcomb, Polly A., Le Marchand, Loic, Lindor, Noralane M., Thibodeau, Stephen N., Goode, Ellen L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3704223/
https://ncbi.nlm.nih.gov/pubmed/23637064
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1055-9965.EPI-12-1226
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