Smoke carcinogens cause bone loss through the aryl hydrocarbon receptor and induction of Cyp1 enzymes

Smoking is a major risk factor for osteoporosis and fracture, but the mechanism through which smoke causes bone loss remains unclear. Here, we show that the smoke toxins benzo(a)pyrene (BaP) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) interact with the aryl hydrocarbon receptor (Ahr) to induce os...

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Autors principals: Iqbal, Jameel, Sun, Li, Cao, Jay, Yuen, Tony, Lu, Ping, Bab, Itai, Leu, N. Adrian, Srinivasan, Satish, Wagage, Sagie, Hunter, Christopher A., Nebert, Daniel W., Zaidi, Mone, Avadhani, Narayan G.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2013
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3704019/
https://ncbi.nlm.nih.gov/pubmed/23776235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1220919110
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