Pyrimidine motif triple helix in the Kluyveromyces lactis telomerase RNA pseudoknot is essential for function in vivo

Telomerase is a ribonucleoprotein complex that extends the 3′ ends of linear chromosomes. The specialized telomerase reverse transcriptase requires a multidomain RNA (telomerase RNA, TER), which includes an integral RNA template and functionally important template-adjacent pseudoknot. The structure...

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Main Authors: Cash, Darian D., Cohen-Zontag, Osnat, Kim, Nak-Kyoon, Shefer, Kinneret, Brown, Yogev, Ulyanov, Nikolai B., Tzfati, Yehuda, Feigon, Juli
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2013
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3704002/
https://ncbi.nlm.nih.gov/pubmed/23776224
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1309590110
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