REGγ deficiency promotes premature aging via the casein kinase 1 pathway

Our recent studies suggest a role for the proteasome activator REG (11S regulatory particles, 28-kDa proteasome activator)γ in the regulation of tumor protein 53 (p53). However, the molecular details and in vivo biological significance of REGγ-p53 interplay remain elusive. Here, we demonstrate that...

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Detalhes bibliográficos
Main Authors: Li, Lei, Zhao, Dengpan, Wei, Haibin, Yao, Liangfang, Dang, Yongyan, Amjad, Ali, Xu, Jinjin, Liu, Jiang, Guo, Linjie, Li, Dongqing, Li, Zhen, Zuo, Di, Zhang, Yuanyuan, Liu, Jian, Huang, Shixia, Jia, Caifeng, Wang, Lu, Wang, Ying, Xie, Yifan, Luo, Jian, Zhang, Bianhong, Luo, Honglin, Donehower, Lawrence A., Moses, Robb E., Xiao, Jianru, O’Malley, Bert W., Li, Xiaotao
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2013
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3703992/
https://ncbi.nlm.nih.gov/pubmed/23766372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1308497110
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