Safety of Oseltamivir Compared With the Adamantanes in Children Less Than 12 Months of Age

BACKGROUND: When oseltamivir is administered in extremely high doses (500–1000 mg/kg) to young juvenile rats, central nervous system toxicity and death occurred in some animals. Mortality was not observed in older juvenile rats, suggesting a possible relationship between neurotoxicity and an immatur...

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Main Authors: Kimberlin, David W., Shalabi, Marwan, Abzug, Mark J., Lang, David, Jacobs, Richard F., Storch, Gregory, Bradley, John S., Wade, Kelly C, Ramilo, Octavio, Romero, José R., Shelton, Mark, Leach, Charles, Guzman-Cottrill, Judith, Robinson, Joan, Abughali, Nazha, Englund, Janet, Griffin, Jill, Jester, Penny, Cloud, Gretchen A., Whitley, Richard J.
Format: Artigo
Sprog:Inglês
Udgivet: 2010
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3703844/
https://ncbi.nlm.nih.gov/pubmed/19949363
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/INF.0b013e3181bbf26b
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