Incorporation of Bulky and Cationic Cyclam-Triazole Moieties into Marimastat Can Generate Potent MMP Inhibitory Activity without Inducing Cytotoxicity

The synthesis and matrix metalloproteinase (MMP) inhibitory activity of a cyclam–marimastat conjugate and its metal complexes are described. The conjugate, synthesized with a copper(I)-catalyzed Huisgen 1,3-dipolar cycloaddition (“click” reaction), contains two zinc-binding groups (ZBGs). The metal...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Yu, Mingfeng, Lim, Ngee H, Ellis, Samantha, Nagase, Hideaki, Triccas, James A, Rutledge, Peter J, Todd, Matthew H
Médium: Artigo
Jazyk:Inglês
Vydáno: WILEY-VCH Verlag 2013
Témata:
Full Papers
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3703814/
https://ncbi.nlm.nih.gov/pubmed/24551546
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/open.201300014
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky