Incorporation of Bulky and Cationic Cyclam-Triazole Moieties into Marimastat Can Generate Potent MMP Inhibitory Activity without Inducing Cytotoxicity

The synthesis and matrix metalloproteinase (MMP) inhibitory activity of a cyclam–marimastat conjugate and its metal complexes are described. The conjugate, synthesized with a copper(I)-catalyzed Huisgen 1,3-dipolar cycloaddition (“click” reaction), contains two zinc-binding groups (ZBGs). The metal...

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Detalhes bibliográficos
Main Authors: Yu, Mingfeng, Lim, Ngee H, Ellis, Samantha, Nagase, Hideaki, Triccas, James A, Rutledge, Peter J, Todd, Matthew H
Formato: Artigo
Idioma:Inglês
Publicado em: WILEY-VCH Verlag 2013
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3703814/
https://ncbi.nlm.nih.gov/pubmed/24551546
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/open.201300014
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