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To Charge or Not to Charge: Mechanistic Insights into Neuropathy-Associated tRNA Synthetase Mutations
Aminoacyl-tRNA synthetases (ARSs) are ubiquitously expressed, essential enzymes responsible for the first step of protein translation—attaching amino acids to cognate tRNA molecules. Interestingly, ARS gene mutations have been implicated in tissue-specific human diseases, including inherited periphe...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3703498/ https://ncbi.nlm.nih.gov/pubmed/23465884 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.gde.2013.02.002 |
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