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Predicting the Pathogenicity of Aminoacyl-tRNA Synthetase Mutations
Aminoacyl-tRNA synthetases (ARSs) are ubiquitously expressed, essential enzymes responsible for charging tRNA with cognate amino acids—the first step in protein synthesis. ARSs are required for protein translation in the cytoplasm and mitochondria of all cells. Surprisingly, mutations in 28 of the 3...
Guardat en:
| Publicat a: | Methods |
|---|---|
| Autors principals: | , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2016
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5253330/ https://ncbi.nlm.nih.gov/pubmed/27876679 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymeth.2016.11.013 |
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