Chromatin Effector Pygo2 Mediates Wnt-Notch Cross-talk to Suppress Luminal/Alveolar Potential of Mammary Stem and Basal Cells

Epigenetic mechanisms regulating lineage differentiation of mammary stem cells (MaSCs) remain poorly understood. Pygo2 is a histone methylation reader and a context-dependent Wnt/β-catenin co-activator. Here we provide evidence for Pygo2’s function in suppressing luminal/alveolar differentiation of...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Gu, Bingnan, Watanabe, Kazuhide, Sun, Peng, Fallahi, Magid, Dai, Xing
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2013
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3703489/
https://ncbi.nlm.nih.gov/pubmed/23684539
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2013.04.012
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