Analgesic effect of a mixed T-type channel inhibitor/CB(2) receptor agonist

BACKGROUND: Cannabinoid receptors and T-type calcium channels are potential targets for treating pain. Here we report on the design, synthesis and analgesic properties of a new mixed cannabinoid/T-type channel ligand, NMP-181. RESULTS: NMP-181 action on CB(1) and CB(2) receptors was characterized in...

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Detalhes bibliográficos
Main Authors: Gadotti, Vinicius M, You, Haitao, Petrov, Ravil R, Berger, N Daniel, Diaz, Philippe, Zamponi, Gerald W
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2013
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3703287/
https://ncbi.nlm.nih.gov/pubmed/23815854
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1744-8069-9-32
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