Safety, tolerability, pharmacokinetics and pharmacodynamics of losmapimod following a single intravenous or oral dose in healthy volunteers

AIMS: The purpose of this study was to establish safety and tolerability of a single intravenous (IV) infusion of a p38 mitogen-activated protein kinase inhibitor, losmapimod, to obtain therapeutic levels rapidly for a potential acute coronary syndrome indication. Pharmacokinetics (PK) following IV...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Barbour, April M, Sarov-Blat, Lea, Cai, Gengqian, Fossler, Michael J, Sprecher, Dennis L, Graggaber, Johann, McGeoch, Adam T, Maison, Jo, Cheriyan, Joseph
Format: Artigo
Sprache:Inglês
Veröffentlicht: Blackwell Science Inc 2013
Schlagworte:
Pharmacokinetic Dynamic Relationships
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3703232/
https://ncbi.nlm.nih.gov/pubmed/23215699
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.12063
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