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Optimizing drug development of anti-cancer drugs in children using modelling and simulation

Modelling and simulation (M&S)-based approaches have been proposed to support paediatric drug development in order to design and analyze clinical studies efficiently. Development of anti-cancer drugs in the paediatric population is particularly challenging due to ethical and practical constraint...

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Detalhes bibliográficos
Main Authors: van Hasselt, Johan GC, van Eijkelenburg, Natasha KA, Beijnen, Jos H, Schellens, Jan HM, Huitema, Alwin DR
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3703226/
https://ncbi.nlm.nih.gov/pubmed/23216601
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.12062
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