Tocilizumab infusion therapy normalizes inflammation in sporadic ALS patients

Patients with sporadic amyotrophic lateral sclerosis (sALS) show inflammation in the spinal cord and peripheral blood. The inflammation is driven by stimulation of macrophages by aggregated superoxide dismutase 1 (SOD1) through caspase1, interleukin 1 (IL1), IL6 and chemokine signaling. Inflammatory...

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Hlavní autoři: Fiala, Milan, Mizwicki, Mathew T, Weitzman, Rachel, Magpantay, Larry, Nishimoto, Norihiro
Médium: Artigo
Jazyk:Inglês
Vydáno: e-Century Publishing Corporation 2013
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3703125/
https://ncbi.nlm.nih.gov/pubmed/23844337
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