Lactoferricin mediates Anti-Inflammatory and Anti-Catabolic Effects via Inhibition of IL-1 and LPS Activity in the Intervertebral Disc

The catabolic cytokine interleukin-1 (IL-1) and endotoxin lipopolysaccharide (LPS) are well-known inflammatory mediators involved in degenerative disc disease, and inhibitors of IL-1 and LPS may potentially be used to slow or prevent disc degeneration in vivo. Here, we elucidate the striking anti-ca...

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Main Authors: Kim, Jae-Sung, Ellman, Michael B., Yan, Dongyao, An, Howard S., Kc, Ranjan, Li, Xin, Chen, Di, Xiao, Guozhi, Cs-Zabo, Gabriella, Hoskin, David W., Buechter, D.D., Van Wijnen, Andre J., Im, Hee-Jeong
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3703102/
https://ncbi.nlm.nih.gov/pubmed/23460134
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcp.24350
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