Intracellularly-Retained Decorin Lacking the C-Terminal Ear Repeat Causes ER Stress: A Cell-Based Etiological Mechanism for Congenital Stromal Corneal Dystrophy

Decorin, a small leucine-rich proteoglycan (SLRP), is involved in the pathophysiology of human congenital stromal corneal dystrophy (CSCD). This disease is characterized by corneal opacities and vision impairment. In reported cases, the human gene encoding decorin contains point mutations in exon 10...

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Autori principali: Chen, Shoujun, Sun, Mei, Iozzo, Renato V., Kao, Winston W.-Y., Birk, David E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Investigative Pathology 2013
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Regular Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3702738/
https://ncbi.nlm.nih.gov/pubmed/23685109
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2013.04.001
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