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Intracellularly-Retained Decorin Lacking the C-Terminal Ear Repeat Causes ER Stress: A Cell-Based Etiological Mechanism for Congenital Stromal Corneal Dystrophy
Decorin, a small leucine-rich proteoglycan (SLRP), is involved in the pathophysiology of human congenital stromal corneal dystrophy (CSCD). This disease is characterized by corneal opacities and vision impairment. In reported cases, the human gene encoding decorin contains point mutations in exon 10...
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| Main Authors: | , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
American Society for Investigative Pathology
2013
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3702738/ https://ncbi.nlm.nih.gov/pubmed/23685109 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2013.04.001 |
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