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Redox Signaling via Oxidative Inactivation of PTEN Modulates Pressure-Dependent Myogenic Tone in Rat Middle Cerebral Arteries

The present study examined the level of generation of reactive oxygen species (ROS) and roles of inactivation of the phosphatase PTEN and the PI3K/Akt signaling pathway in response to an increase in intramural pressure-induced myogenic cerebral arterial constriction. Step increases in intraluminal p...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Gebremedhin, Debebe, Terashvili, Maia, Wickramasekera, Nadi, Zhang, David X., Rau, Nicole, Miura, Hiroto, Harder, David R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2013
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3702596/
https://ncbi.nlm.nih.gov/pubmed/23861911
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0068498
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