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Novel structure-function information on biogenic amine transporters revealed by site-directed mutagenesis and alkylation
The study reported by Wenge and Bönisch in this issue provides critical structural information regarding extracellular loop 2 (EL2) of the human norepinephrine transporter (NET). A systematic search among all 10 cysteine and 13 histidine residues in NET led to His222 in EL2 as the target for N-ethyl...
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| Auteur principal: | |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2013
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3702163/ https://ncbi.nlm.nih.gov/pubmed/23532308 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11064-013-1025-0 |
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