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A Critical Role for the Inducible Proteasomal Subunits LMP7 and MECL1 in Cytokine Production by Activated Murine Splenocytes

BACKGROUND AND PURPOSE: The proteasome is a multi-subunit complex that proteolytically cleaves proteins. The replacement of the constitutive proteasome subunits β1, β2, and/or β5 with the IFNγ-inducible subunits LMP2, MECL1, and/or LMP7 results in the ‘immunoproteasome’. The inducible subunits chang...

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Detalles Bibliográficos
Main Authors: Rockwell, Cheryl E., Monaco, John J., Qureshi, Nilofer
Formato: Artigo
Idioma:Inglês
Publicado: S. Karger AG 2012
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3702019/
https://ncbi.nlm.nih.gov/pubmed/22398747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000336335
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