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Experimental Models for Identifying Modifiers of Polyglutamine-Induced Aggregation and Neurodegeneration
Huntington’s disease (HD) typifies a class of inherited neurodegenerative disorders in which a CAG expansion in a single gene leads to an extended polyglutamine tract and misfolding of the expressed protein, driving cumulative neural dysfunction and degeneration. HD is invariably fatal with symptoms...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Springer US
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3701774/ https://ncbi.nlm.nih.gov/pubmed/23700210 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13311-013-0195-4 |
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