Rap1 relocalization contributes to the chromatin-mediated gene expression profile and pace of cell senescence

Cellular senescence is accompanied by dramatic changes in chromatin structure and gene expression. Using Saccharomyces cerevisiae mutants lacking telomerase (tlc1Δ) to model senescence, we found that with critical telomere shortening, the telomere-binding protein Rap1 (repressor activator protein 1)...

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Detalhes bibliográficos
Main Authors: Platt, Jesse M., Ryvkin, Paul, Wanat, Jennifer J., Donahue, Greg, Ricketts, M. Dan, Barrett, Steven P., Waters, Hannah J., Song, Shufei, Chavez, Alejandro, Abdallah, Khaled Omar, Master, Stephen R., Wang, Li-San, Johnson, F. Brad
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2013
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3701195/
https://ncbi.nlm.nih.gov/pubmed/23756653
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.218776.113
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