Loss of MCL-1 leads to impaired autophagy and rapid development of heart failure

Myeloid cell leukemia-1 (MCL-1) is an anti-apoptotic BCL-2 protein that is up-regulated in several human cancers. MCL-1 is also highly expressed in myocardium, but its function in myocytes has not been investigated. We generated inducible, cardiomyocyte-specific Mcl-1 knockout mice and found that ab...

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Main Authors: Thomas, Robert L., Roberts, David J., Kubli, Dieter A., Lee, Youngil, Quinsay, Melissa N., Owens, Jarvis B., Fischer, Kimberlee M., Sussman, Mark A., Miyamoto, Shigeki, Gustafsson, Åsa B.
Formato: Artigo
Idioma:Inglês
Publicado: Cold Spring Harbor Laboratory Press 2013
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Research Paper
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3701192/
https://ncbi.nlm.nih.gov/pubmed/23788623
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.215871.113
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