Centenarians as super-controls to assess the biological relevance of genetic risk factors for common age-related diseases: A proof of principle on type 2 diabetes

Genetic association studies of age-related, chronic human diseases often suffer from a lack of power to detect modest effects. Here we propose an alternative approach of including healthy centenarians as a more homogeneous and extreme control group. As a proof of principle we focused on type 2 diabe...

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Autori principali: Garagnani, Paolo, Giuliani, Cristina, Pirazzini, Chiara, Olivieri, Fabiola, Bacalini, Maria Giulia, Ostan, Rita, Mari, Daniela, Passarino, Giuseppe, Monti, Daniela, Bonfigli, Anna Rita, Boemi, Massimo, Ceriello, Antonio, Genovese, Stefano, Sevini, Federica, Luiselli, Donata, Tieri, Paolo, Capri, Miriam, Salvioli, Stefano, Vijg, Jan, Suh, Yousin, Delledonne, Massimo, Testa, Roberto, Franceschi, Claudio
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals LLC 2013
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3701112/
https://ncbi.nlm.nih.gov/pubmed/23804578
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